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Understanding Psoriasis Injections: What They Are and How They Help

Psoriasis is a chronic autoimmune skin condition that causes red, scaly patches on the skin, often accompanied by itching, pain, or discomfort.

While many people manage psoriasis with topical treatments or oral medications, moderate to severe cases may require injection-based therapies for more effective, long-term control.

This article explains what psoriasis injections are, the types available, how they work, and what patients should know before starting this form of treatment.

What Are Psoriasis Injections?

Psoriasis injections are medications delivered directly into the body via subcutaneous (under the skin) or intramuscular (into the muscle) injections. They are designed to target the immune system to reduce inflammation and slow down the rapid skin cell turnover that causes psoriasis plaques.

These treatments are typically used when:

  • Topical treatments and phototherapy are not enough
  • The psoriasis covers a large portion of the body
  • The disease significantly impacts a patient’s quality of life
  • Psoriatic arthritis (joint inflammation) is also present

Types of Psoriasis Injections

There are two main categories of injections used for psoriasis:

1. Biologic Drugs (Biologics)

Biologics are advanced, targeted therapies made from living cells. They are designed to block specific parts of the immune system involved in psoriasis.

Common biologics for psoriasis include:

  • TNF-alpha inhibitors: Adalimumab (Humira), Etanercept (Enbrel), Infliximab (Remicade)
  • IL-12/23 inhibitors: Ustekinumab (Stelara)
  • IL-17 inhibitors: Secukinumab (Cosentyx), Ixekizumab (Taltz), Brodalumab (Siliq)
  • IL-23 inhibitors: Guselkumab (Tremfya), Risankizumab (Skyrizi), Tildrakizumab (Ilumya)

Biologics are usually given via subcutaneous injection (self-administered or given by a healthcare provider) every few weeks to months, depending on the specific drug.

2. Systemic Injectable Medications

For some patients, especially those with severe psoriasis, methotrexate may be used as an injectable option. Although more commonly taken orally, it can be administered via injection for better absorption or when oral delivery causes side effects.

How Do Psoriasis Injections Work?

Psoriasis injections work by modulating the immune system, specifically:

  • Blocking inflammatory proteins (cytokines) like TNF-alpha, IL-17, or IL-23
  • Reducing the immune system’s overactive response
  • Slowing the excessive skin cell turnover that leads to plaque formation

By addressing the root cause of the disease, these treatments can significantly reduce symptoms, clear skin lesions, and improve patients’ quality of life.

Who Should Consider Psoriasis Injections?

Psoriasis injections are typically prescribed for:

  • Patients with moderate to severe plaque psoriasis (covering >10% of the body)
  • Those with psoriatic arthritis
  • Individuals who have not responded well to topicals, phototherapy, or oral medications
  • Patients seeking longer-lasting or more convenient treatment compared to daily therapies

Not everyone is a candidate for biologic treatments, especially those with certain infections, immune conditions, or a history of cancer, so careful screening is essential.

What Are the Benefits and Risks?

Benefits of psoriasis injections include:

  • High effectiveness for moderate to severe psoriasis
  • Longer-lasting symptom control compared to topicals
  • Convenience (some injections are only needed every 4–12 weeks)

Risks and side effects can include:

  • Injection site reactions (redness, pain, swelling)
  • Increased risk of infections (since the immune system is suppressed)
  • Rare but serious risks like tuberculosis reactivation or liver issues (patients are screened before starting treatment)

Regular monitoring by a healthcare provider is important while on these therapies.

Final Thoughts

Psoriasis injections offer a powerful treatment option for individuals struggling with moderate to severe psoriasis or psoriatic arthritis. While they are not a cure, these medications can significantly reduce symptoms and improve skin appearance and quality of life.

If you’re considering psoriasis injections, consult with a dermatologist or rheumatologist to discuss whether you are a good candidate, what screening tests are needed, and which medication may best suit your needs.