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5 New Treatments for Polymyalgia Rheumatica You Should Know About

Polymyalgia rheumatica causes stiffness, fatigue, and deep muscle pain—often making mornings unbearable. But newer treatments are now offering relief for those who don’t respond well to steroids or want alternatives. From advanced injections to immune-targeting therapies, relief may be closer than ever.

Here are 5 of the most promising new PMR treatments, with #5 being the most surprising.

1. Sarilumab Injection (Kevzara®)

Sarilumab, originally used for rheumatoid arthritis, is now being studied and used off-label for PMR. It works by blocking the IL-6 receptor, a key driver of inflammation in PMR.

  • How it helps: Reduces reliance on corticosteroids
  • Dose: Subcutaneous injection every 2 weeks
  • Why it matters: It offers relief for steroid-resistant or steroid-intolerant patients

2. Tocilizumab (Actemra®)

Like sarilumab, tocilizumab is an IL-6 inhibitor. Recent trials show it can effectively control symptoms and help taper off prednisone safely.

  • How it helps: Manages flare-ups and reduces muscle stiffness
  • Delivery: Given as an injection or IV infusion
  • Why it matters: It provides another targeted option with minimal steroid exposure

3. Methotrexate (Low-Dose Therapy)

Though not new to autoimmune conditions, low-dose methotrexate is gaining traction for long-term PMR management—especially in patients needing steroid-sparing strategies.

  • How it helps: Reduces inflammation and supports steroid tapering
  • Delivery: Weekly oral or injectable doses
  • Why it matters: May help prevent relapses and lower long-term steroid side effects

4. JAK Inhibitors (Investigational Use)

JAK inhibitors, such as upadacitinib, are being evaluated for autoimmune diseases, including PMR. They target the Janus kinase pathway, which plays a role in inflammatory cytokine signaling.

  • How it helps: Reduces systemic inflammation and stiffness
  • Why it matters: Oral option showing promise for future PMR treatment protocols

5. Mediterranean Diet + Anti-Inflammatory Supplements

This may be the most surprising entry: New studies suggest that combining a Mediterranean diet with omega-3 supplements, turmeric, and vitamin D may significantly reduce flare-ups and stiffness.

  • How it helps: Naturally lowers inflammation, supports joint health
  • Why it matters: It’s non-prescription, accessible, and may enhance medication effectiveness
  • Bonus: Also supports heart and bone health, which are critical in PMR patients

Why New Treatments Matter for PMR

Corticosteroids like prednisone are still the primary treatment for PMR—but they come with serious long-term side effects, including:

  • Weight gain
  • Bone thinning (osteoporosis)
  • Mood swings
  • High blood pressure and diabetes risk

New treatments like sarilumab, tocilizumab, and methotrexate are being used to reduce or eliminate long-term steroid use, helping patients regain mobility and quality of life with fewer risks.

Conclusion

Living with PMR doesn’t have to mean endless steroids and constant side effects. With new treatments like sarilumab injections, IL-6 blockers, and even targeted lifestyle changes, relief is within reach. If you're struggling to manage your symptoms, talk to your rheumatologist about these new and evolving options.

Sources

American College of Rheumatology – https://www.rheumatology.org

National Institutes of Health – https://www.nih.gov

Kevzara (Sarilumab) – https://www.kevzara.com

Actemra (Tocilizumab) – https://www.actemra.com

Mayo Clinic – https://www.mayoclinic.org